Publications

Tensorial tomographic Fourier Ptychography with applications to muscle tissue imaging
Shiqi Xu, Xiang Dai, Paul Ritter, Kyung Chul Lee, Xi Yang, Lucas Kreiss, Kevin C. Zhou, …, Roarke Horstmeyer
Advanced Photonics 6(2):026004–026004 (2024)
[link] [arXiv link]
Shot-noise limited optical hybrid based on fused fiber couplers
Kristen Hagan, Kevin C. Zhou, Al-Hafeez Dhalla, Joseph Izatt
Optics Letters 49(2):347–350 (2024)
[link] [Optica Open link]
Digital staining in optical microscopy using deep learning–a review
Lucas Kreiss, Shaowei Jiang, Xiang Li, Shiqi Xu, Kevin C. Zhou, Alexander Mühlberg, Kyung Chul Lee, …, Roarke Horstmeyer
PhotoniX, 4(1):34 (2023)
link] [arXiv link]
Conserved chamber-specific polyploidy maintains heart function in Drosophila
Archan Chakraborty, Nora Peterson, Juliet King, Ryan Gross, Michelle M. Pla, Aatish Thennavan, Kevin C. Zhou, …, Donald Fox
Development 150(16) (2023)
[link] [bioRxiv link]
Computational 3D topographic microscopy from terabytes of data per sample
Kevin C. Zhou, Mark Harfouche, Maxwell Zheng, Joakim Jönsson, …, Roarke Horstmeyer
arXiv:2306.02634 (2023)
[link]
Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per second
Kevin C. Zhou, Mark Harfouche, Colin Cooke, Jaehee Park, …, Michel Bagnat, Roarke Horstmeyer
Nature Photonics 17:442–450 (2023)
[link] [open access link] [arXiv link] [pubmed] [code] [data]
Featured in Nature Methods
Imaging across multiple spatial scales with the multi-camera array microscope
Mark Harfouche, Kanghyun Kim, Kevin C. Zhou, Pavan C. Konda, Sunanda Sharma, …, Eva Naumann, Roarke Horstmeyer
Optica 10, 471–480 (2023)
[link] [arXiv link]
Multi-modal imaging using a cascaded microscope design
Xi Yang, Mark Harfouche, Kevin C. Zhou, Lucas Kreiss, Shiqi Xu, Kanghyun Kim, Roarke Horstmeyer
Optics Letters 48, (2023)
[link] [arXiv link]
Tensorial tomographic differential phase-contrast microscopy
Shiqi Xu, Xiang Dai, Xi Yang, Kevin C. Zhou, Kanghyun Kim, Vinayak Pathak, Carolyn Glass, and Roarke Horstmeyer
ICCP (2022)
[link] [arXiv link]
Real-time wide-field spectral-scanning FMCW coherent 3D imaging and velocimetry
Jingkai Zhang, Ruobing Qian, Kevin C. Zhou, Christian Viehland, Mark Draelos, Al-Hafeez Dhalla, Joseph A. Izatt
Optics Letters 47, 4064-4067 (2022)
[link]
Transient motion classification through turbid volumes via parallelized single-photon detection and deep contrastive embedding
Shiqi Xu, Wenhui Liu, Xi Yang, Joakim Jönsson, Ruobing Qian, Paul McKee, Kanghyun Kim, Pavan Chandra Konda, Kevin C. Zhou, Lucas Kreiß, Haoqian Wang, Edouard Berrocal, Scott Huettel, Roarke Horstmeyer
Frontiers in Neuroscience 16 (2022)
[link] [arXiv link]
Imaging dynamics beneath turbid media via parallelized single-photon detection
Shiqi Xu, Xi Yang, Wenhui Liu, Joakim Jonsson, Ruobing Qian, Pavan Chandra Konda, Kevin C. Zhou, Qionghai Dai, Haoqian Wang, Edouard Berrocal, Roarke Horstmeyer
Advanced Science 9(24) (2022)
[link] [arXiv link]
Computational 3D microscopy with optical coherence refraction tomography
Kevin C. Zhou, Ryan P. McNabb, Ruobing Qian, Simone Degan, Al-Hafeez Dhalla, Sina Farsiu, Joseph A. Izatt
Optica 9, 593-601 (2022)
[link] [arXiv link] [pubmed] [code] [data]
Video-rate high-precision time-frequency multiplexed 3D coherent ranging
Ruobing Qian, Kevin C. Zhou, Jingkai Zhang, Christian Viehland, Al-Hafeez Dhalla, Joseph A. Izatt
Nature Communications 13, 1476 (2022)
[link] [arXiv link]
Quantitative Jones matrix imaging using vectorial Fourier ptychography (Editor’s Pick)
Xiang Dai, Shiqi Xu, Xi Yang, Kevin C. Zhou, Carolyn Glass, Pavan Chandra Konda, Roarke Horstmeyer
Biomedical Optics Express 13, 1457-1470 (2022)
[link] [arXiv link]
Increasing a microscope’s effective field of view via overlapped imaging and machine learning
Xing Yao, Vinayak Pathak, Haoran Xi, Amey Chaware, Colin Cooke, Kanghyun Kim, Shiqi Xu, Yuting Li, Timothy Dunn, Pavan Chandra Konda, Kevin C. Zhou, Roarke Horstmeyer
Optics Express 30, 1745-1761 (2022)
[link]
High-speed multi-view imaging approaching 4pi steradians using conic section mirrors: theoretical and practical considerations (Editor’s Pick)
Kevin C. Zhou, Al-Hafeez Dhalla, Ryan P. McNabb, Ruobing Qian, Sina Farsiu, Joseph A. Izatt
JOSA A 38, 1810-1822 (2021)
[link] [arXiv link] [code]
Physics-enhanced machine learning for virtual fluorescence microscopy
Colin L. Cooke, Fanjie Kong, Amey Chaware, Kevin C. Zhou, Kanghyun Kim, Rong Xu, D. Michael Ando, Samuel J. Yang, Pavan Chandra Konda, Roarke Horstmeyer
ICCV (2021)
[link] [arXiv link] [code]
Unified k-space theory of optical coherence tomography
Kevin C. Zhou, Ruobing Qian, Al-Hafeez Dhalla, Sina Farsiu, Joseph A. Izatt
Advances in Optics and Photonics 13, 462-514 (2021)
[link] [arXiv link] [code]
Mesoscopic photogrammetry with an unstabilized phone camera
Kevin C. Zhou, Colin Cooke, Jaehee Park, Ruobing Qian, Roarke Horstmeyer, Joseph A. Izatt, Sina Farsiu
CVPR (2021)
[link] [arXiv link] [code] [data] [poster]
In vivo quantitative analysis of anterior chamber white blood cell mixture composition using spectroscopic optical coherence tomography
Ruobing Qian, Ryan P. McNabb, Kevin C. Zhou, Hazem M. Mousa, Daniel R. Saban, Victor L. Perez, Anthony N. Kuo, Joseph A. Izatt
Biomedical Optics Express 12, 2134-2148 (2021)
[link]
Optical coherence tomography-guided robotic ophthalmic microsurgery via reinforcement learning from demonstration
Brenton Keller, Mark Draelos, Kevin C. Zhou, Ruobing Qian, Anthony N. Kuo, George Konidaris, Kris Hauser, Joseph A. Izatt
IEEE Transactions on Robotics (2020)
[link]
Diffraction tomography with a deep image prior
Kevin C. Zhou, Roarke Horstmeyer
Optics Express 28, 12872-12896 (2020)
[link] [arXiv link] [code] [data] [project page]
Spectroscopic optical coherence refraction tomography
Kevin C. Zhou, Ruobing Qian, Sina Farsiu, Joseph A. Izatt
Optics Letters 45, 2091-2094 (2020)
[link] [code] [data]
Fourier ptychography: current applications and future promises
Pavan Chandra Konda*, Lars Loetgering*, Kevin C. Zhou*, Shiqi Xu, Andrew R. Harvey, Roarke Horstmeyer
*Equal contribution
Optics Express 28, 9603-9630 (2020)
[link]
Learned sensing: jointly optimized microscope hardware for accurate image classification (Editor’s Pick)
Alex Muthumbi, Amey Chaware, Kanghyun Kim, Kevin C. Zhou, Pavan Chandra Konda, Richard Chen, Benjamin Judkewitz, Andreas Erdmann, Barbara Kappes, Roarke Horstmeyer
Biomedical Optics Express 10, 6351-6369 (2019)
[link] [code] [data]
Optical coherence refraction tomography
Kevin C. Zhou, Ruobing Qian, Simone Degan, Sina Farsiu, Joseph A. Izatt
Nature Photonics 13, 794–802 (2019)
[link] [open access link 1] [open access link 2] [code] [data]
Featured in Nature Methods, Optics & Photonics News, and Scientific American
Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography
Ruobing Qian, Wei-feng Huang, Ryan P. McNabb, Kevin C. Zhou, Qing H. Liu, Anthony N. Kuo, Joseph A. Izatt
Biomedical Optics Express 10, 3281-3300 (2019)
[link]
Unraveling the molecular nature of melanin changes in metastatic cancer
Kuk-Youn Ju, Simone Degan, Martin C. Fischer, Kevin C. Zhou, Xiaomeng Jia, Jin Yu, Warren S. Warren
Journal of Biomedical Optics 24, 051414 (2019)
[link]
Stimulated Raman scattering spectroscopic optical coherence tomography
Francisco E. Robles, Kevin C. Zhou, Martin C. Fischer, Warren S. Warren
Optica 4, 243-246 (2017)
[link]
Biaxial stretch improves elastic fiber maturation, collagen arrangement, and mechanical properties in engineered arteries
Angela H. Huang, Jenna L. Balestrini, Brooks V. Udelsman, Kevin C. Zhou, Liping Zhao, Jacopo Ferruzzi, Barry C. Starcher, Michael J. Levene, Jay D. Humphrey, Laura E. Niklason
Tissue Engineering Part C: Methods 22, 524-533 (2016)
[link]
Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows
Kevin C. Zhou, Brendan K. Huang, Ute A. Gamm, Vineet Bhandari, Mustafa K. Khokha, Michael A. Choma
Biomedical Optics Express 7, 1590-1603 (2016)
[link]
Improved velocimetry in optical coherence tomography using Bayesian analysis
Kevin C. Zhou, Brendan K. Huang, Hemant Tagare, Michael A. Choma
Biomedical Optics Express 6, 4796-4811 (2015)
[link]
Quantifying uncertainty in the phylogenetics of Australian numeral systems
Kevin C. Zhou, Claire Bowern
Proceedings of the Royal Society B: Biological Sciences 282, 20151278 (2015)
[link]
Featured in Science
The use of optical clearing and multiphoton microscopy for investigation of three-dimensional tissue-engineered constructs
Elizabeth A. Calle, Sam Vesuna, Sashka Dimitrievska, Kevin C. Zhou, Angela Huang, Liping Zhao, Laura E. Niklason, Michael J. Levene
Tissue Engineering Part C: Methods 20, 570-577 (2014)
[link]
Developmental modification of synaptic NMDAR composition and maturation of glutamatergic synapses: matching postsynaptic slots with receptor pegs
Erin M. Sanders, Michael A. Nguyen, Kevin C. Zhou, Mary E. Hanks, Kawthar A. Yusuf, Daniel N. Cox, Theodore C. Dumas
The Biological Bulletin 224, 1-13 (2013)
[link]

Conferences and invited seminars

High-throughput computational microscopy with diffractive multiplexing across a gigapixel sensor array
Kevin C. Zhou, Chaoying Gu, Grace Jiang, Nick Antipa, Roarke Horstmeyer, and Laura Waller
SPIE Photonics West (2024)
Tomographic behavioral tracking of freely-moving model organisms with a hemispheric Fourier light field microscope
Kevin C. Zhou, Clare Cook, Archan Chakraborty, Joakim Jönsson, Kyung Chul Lee, Xi Yang, Shiqi Xu, Jennifer Bagwell, Don Fox, Michel Bagnat, and Roarke Horstmeyer
SPIE Photonics West (2024)
Fourier light field camera array mesoscope for video-rate 3D imaging
Clare B. Cook, Kevin C. Zhou, and Roarke Horstmeyer
SPIE Photonics West (2024)
Line-scan phase-resolved synthetic wavelength LiDAR using an off-axis holographic approach
Jingkai Zhang, Joseph A. Izatt, Robert Trout, Jianwei D. Li, Julia S. Foust, Al-Hafeez Dhalla, and Kevin C. Zhou
SPIE Photonics West (2024)
High-content multimodal in vivo imaging using a parallelized gigapixel scale microscope
Xi Yang, Aurelian Bègue, Mark Harfouche, Clare Cook, Kanghyun Kim, Kevin C. Zhou, and Roarke Horstmeyer
SPIE Photonics West (2024)
Computational wavefront shaping with epi-mode 3D refractive index microscopy
Mingxuan Cai, Kevin C. Zhou, Yi Xue, and Laura Waller
Optica Imaging Congress (2023)
Computational 3D topographic microscopy from terabytes of data per sample
Kevin C. Zhou, Mark Harfouche, Maxwell Zheng, Joakim Jönsson, Kyung Chul Lee, Ron Appel, Paul Reamey, Thomas Doman, Veton Saliu, Gregor Horstmeyer, and Roarke Horstmeyer
Optica Imaging Congress (2023)
Fourier light field camera array microscope for mesoscale 3D imaging
Clare Cook, Kevin C. Zhou, and Roarke Horstmeyer
Optica Imaging Congress (2023)
Anisotropic intensity diffraction tomography
Shiqi Xu, Xiang Dai, Xi Yang, Kyung Chul Lee, Lucas Kreiss, Kevin C. Zhou, Kanghyun Kim, Amey Chaware, and Roarke Horstmeyer
Optica Imaging Congress (2023)
High-throughput imaging across multiple spatial scales with the multi-camera array microscope (MCAM)
Lucas Kreiss, Kevin C. Zhou, Kanghyun Kim, Mark Harfouche, Shiqi Xu, Joakim Jönsson, Kyung Chul Lee, Clare Cook, Xi Yang, Paul Reamey, … Roarke Horstmeyer
SPIE Optical Metrology (2023)
[link]
High-throughput tomographic fluorescence imaging with a synchronized camera array
Kevin C. Zhou, Joakim Jönsson, Clare Cook, Kyung Chul Lee, Xi Yang, Shiqi Xu, Jennifer Bagwell, Archan Chakraborty, Donald Fox, Michel Bagnat, and Roarke Horstmeyer
SPIE Photonics West (2023)
[link]
Multi-modal imaging with a parallelized 16-gigapixel microscope
Kamghyun Kim, Kevin C. Zhou, Mark Harfouche, and Roarke Horstmeyer
SPIE Photonics West (2023)
[link]
Real-time, wide-FOV spectral-scanning FMCW 3D imaging and velocimetry
Jingkai Zhang, Ruobing Qian, Kevin C. Zhou, Christian Viehland, Al-Hafeez Dhalla, and Joseph A. Izatt
Frontiers in Optics + Laser Science 2022
Using machine learning to accelerate image classification and quantification in highly parallelized gigapixel multi-camera array microscopes
Mark Harfouche, John Efromson, Thomas Doman, Paul Reamey, Veton Saliu, Ron Appel, Jack Bechtel, Kevin C. Zhou, Kanghyun Kim, Eric Thomson, and Guiliano Ferrero
Frontiers in Optics + Laser Science 2022
Gigapixel-per-second, wide-field 3D topographic imaging with physics-supervised learning
Kevin C. Zhou, Mark Harfouche, Colin Cooke, Jaehee Park, Pavan Konda, Jed Doman, Paul Reamey, Veton Saliu, Maxwell Zheng, Gregor Horstmeyer, Roarke Horstmeyer Imaging and Applied Optics Congress 2022
[link]
Parallelized 16-gigapixel microscopy for rapid imaging of multiple whole slides
Kanghyun Kim, Kevin C. Zhou, Mark Harfouche, Roarke Horstmeyer
Imaging and Applied Optics Congress 2022
[link]
Towards gigavoxel computational 3D imaging at the mesoscale (Invited joint seminar)
Kevin C. Zhou, Roarke Horstmeyer
HHMI Janelia Research Campus (2022)
High-throughput computational 3D imaging with a synchronized camera array
Kevin C. Zhou, Mark Harfouche, Roarke Horstmeyer
Gordon Image Science Conference (2022)
Parallelized microscopy for teravoxel whole-slide imaging
Roarke Horstmeyer, Kanghyun Kim, Mark Harfouche, Gregor Horstmeyer, Paul Reamey, Shiqi Xu, Vinayak Pathak, Kevin C. Zhou, Amey Chaware, and Sara Jiang
Optica Biophotonics (2022)
3D optical coherence refraction tomography using a parabolic mirror (Talk)
Kevin C. Zhou, Ryan P. McNabb, Ruobing Qian, Simone Degan, Al-Hafeez Dhalla, Sina Farsiu, and Joseph A. Izatt
SPIE Photonics West (2022)
[link]
Real-time FMCW 3D imaging for various room-scale applications
Jingkai Zhang, Joseph A. Izatt, Ruobing Qian, Al-Hafeez Dhalla, Kevin C. Zhou, and Christian Viehland.
SPIE Photonics West (2022)
Imaging anisotropy with vectorial Fourier ptychography
Shiqi Xu, Xiang Dai, Xi Yang, Kevin C. Zhou, Pavan Konda, and Roarke Horstmeyer
Computational Optics 2021, SPIE (2021)
[link]
Incoherent 3D k-space synthesis with volumetric optical coherence refraction tomography (Best student paper award)
Kevin C. Zhou, Ruobing Qian, Al-Hafeez Dhalla, Sina Farsiu, and Joseph A. Izatt
OSA Imaging and Applied Optics Congress (2021)
[link]
Increasing a microscope’s effective field of view via overlapped imaging and machine learning
Xing Yao, Haoran Xi, Kevin C. Zhou, Amey Chaware, Colin Cooke, Yuting Li, Timothy Dunn, Pavan Konda, and Roarke Horstmeyer
OSA Imaging and Applied Optics Congress (2021)
Computational 3D imaging, from optical coherence tomography and microscopes to your smartphone (Invited seminar)
Kevin C. Zhou
Fitzpatrick Institute for Photonics (FIP), 2021.
Snapshot 3D imaging with a gigapixel-scale multi-aperture microscope (Talk)
Kevin C. Zhou, Colin Cooke, Jaehee Park, Pavan Chandra Konda, Mark Harfouche, Roarke Horstmeyer
SPIE Photonics West 2021 (online conference).
[link]
Resolution enhancement and speckle reduction in coherence imaging: a k-space model of optical coherence refraction tomography (OCRT) (Invited talk) (OSA Biophotonics Student Award)
Kevin C. Zhou, Ruobing Qian, Sina Farsiu, Joseph A. Izatt
OSA Biophotonics Congress 2020.
[link]
Optical coherence refraction tomography (Invited seminar)
Kevin C. Zhou
Berkeley Center for Computational Imaging (BCCI), 2020.
High-resolution 3D imaging using Fourier ptychographic tomography with a deep image prior (Talk)
Kevin C. Zhou, Roarke Horstmeyer
SPIE Photonics West 2020, San Francisco, CA.
Optical coherence refraction tomography (Invited seminar)
Kevin C. Zhou
Advanced Research Center for Nanolithography (ARCNL), Netherlands, 2019.
Improving diffraction tomography with intensity-only images (Invited talk)
Kevin C. Zhou
Face2phase 2019, TU Delft Science Center, Delft, Netherlands.
[link]
Spectroscopic optical coherence refraction tomography for isotropically resolved imaging with simultaneously high spatial and spectral resolution (Talk)
Kevin C. Zhou, Ruobing Qian, Sina Farsiu, Joseph A. Izatt
SPIE Photonics West 2019, San Francisco, CA.
Optical coherence refraction tomography for isotropically resolved cross-sectional imaging (Talk)
Kevin C. Zhou, Ruobing Qian, Sina Farsiu, Joseph A. Izatt
SPIE Photonics West 2018, San Francisco, CA.
Stimulated Raman scattering (SRS) spectroscopic OCT
Francisco E. Robles, Kevin C. Zhou, Martin C. Fischer, Warren S. Warren
SPIE Photonics West 2017, San Francisco, CA.
Visualizing convolutional neural networks for extracting structural and chemical information from pump-probe microscopy of melanoma (Poster)
Kevin C. Zhou, Francisco E. Robles, Martin C. Fischer, Warren S. Warren
World Molecular Imaging Congress 2016, New York City, NY.
Towards all-optical quantification of ciliary physiology
Brendan K. Huang, Ikbal Sencan, Ute A. Gamm, Kevin C. Zhou, Changgeng Liu, Yong Bian, Zhilong Cong, Sebastian Knitter, Hui Cao, Michael Loewenberg, Mustafa K. Khokha, Michael A. Choma
OSA CLEO: Applications and Technology 2016, San Jose, CA.
[link]
OCT-based three-dimensional, three vector component imaging of cilia-driven fluid flow for developmental biology
Brendan K. Huang, Kevin C. Zhou, Ute A. Gamm, Vineet Bhandari, Mustafa K. Khokha, Michael A. Choma
SPIE Photonics West 2016, San Francisco, CA.
[link]
Particle streak velocimetry-OCT (PSV-OCT): a novel method for multi-vector component velocimetry of microscale flow physiology (Talk)
Kevin C. Zhou, Brendan K. Huang, Ute A. Gamm, Vineet Bhandari, Mustafa K. Khokha, Michael A. Choma
SPIE Photonics West 2016, San Francisco, CA.
[link]
Multiphoton microscopy of cleared human tissue for 3D histology
Michael J. Levene, Kevin C. Zhou, Sam Vesuna, Richard Torres
OSA Novel Techniques in Microscopy 2013, Waikoloa Beach, Hawaii.
[link]

Non-peer-reviewed publications

Applications and Extensions of Fourier Ptychography
Tomas Aidukas, Felix Wechsler, Lars Loetgering, Kevin C. Zhou, Roarke Horstmeyer
Microscopy Today 30(6), 40-45 (2022)
[link]
Fourier Ptychography Part II: Phase Retrieval and High-Resolution Image Formation
Lars Loetgering, Tomas Aidukas, Kevin C. Zhou, Felix Wechsler, Roarke Horstmeyer
Microscopy Today 30(5), 36-39 (2022)
[link]
Spotlight on optics: Simultaneous multiple time scale imaging for kHz–MHz high-speed accelerometry
Kevin C. Zhou
Spotlight summary of Photon. Res. 10(7) 1712-1722 (2022)
[link] [link to summarized paper]
Introduction to Fourier Ptychography: Part I
Kevin C. Zhou, Tomas Aidukas, Lars Loetgering, Felix Wechsler, Roarke Horstmeyer
Microscopy Today 30(3), 36-41 (2022)
[link]
Optical coherence refraction tomography
Kevin C. Zhou, Sina Farsiu, Joseph A. Izatt
Optics and Photonics News 32, 30-37 (2021)
[link] [nature photonics link]

Kevin C. Zhou

Publications

Conferences and invited seminars

Non-peer-reviewed publications